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Since moving to 64-bit I've found the odd problem but nothing prohibitive. So it is with a difficulty in running some Windows applications in 32-bit versions of Wine, including the excellent Crossover Office The problems seem to be in file system access ... when you attempt a save from the Windows program you exit without error. Happily 64-bit Wine is available, and a 64-bit version of Crossover is promised in the 6.2 release. There's some beating the bushes in terms of Wine's requirement for an HTML rendering engine - typically the auto-install has been failing. Here's how to set up a working 64-bit Wine access to a Windows EXE. Use the regular means to install the EXE -- I use Crossover office, then just point Wine to the installed directory. The install below is for a Feisty 64 bit installation; make repository adjustments as needed.

1. Install Wine. The following steps get a key for the budgetdedicated repository for feisty, add the repository to your list, and install wine.
   $ wget -q http://wine.budgetdedicated.com/apt/387EE263.gpg -O- | sudo apt-key add -
$ sudo wget http://wine.budgetdedicated.com/apt/sources.list.d/feisty.list -O /etc/apt/sources.list.d/winehq.list $ sudo apt-get update
$sudo apt-get install wine




   
2. Install the Gecko engine that picks up the slack when a Windows program calls on their proprietary browser. Do this before you run your Windows program
   $ wine iexplore http://www.winehq.org
   
3. Run your Windows program
   $ wine "/home/whoiam/.cxoffice/win2000Unsupported/drive_c/Program Files/SomeDir/SomeFile.exe"